Semi-chronic toxicity study of the extracts from different parts of burmese-grape Baccaurea ramiflora fruits of Ha Chau variety using mouse model
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Abstract
This study evaluated the semi-chronic toxicity of seed, peel, and pulp extracts from burmese-grape fruits of Ha Chau variety on Swiss albino mice. The ethanolic extract from peels and seeds as well as fruit juice from squeezing pulp were dried under a vacuum to obtain the crude extracts. The distilled water (control group) or these extracts at a daily dose of 400 mg/kg of body weight were directly inserted into the stomach of mice for 90 days. The mice were observed for toxicity signs, externally morphological features of organs, and histopathology after 45- and 90-days of treatment. The results revealed that there were no toxicity signs and statistically insignificant differences in body weight gain, the ratio of organ weight to body weight, and blood glucose level at 45 days of treatment. At 90 days of treatment, similar results were observed, except that the ratio of kidney weight to body weight significantly increased in peel extract mouse group as compared to the control. The semi-chronic toxicity assessment showed that Ha Chau fruit (HCF) seed and pulp extracts were safe at a daily dose of 400mg/kg for 90 days in mice and that HCF peel extract was safe when orally...
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