Synthesis and acute toxicity evaluation of Hantzsch 1,4-dihydropyridine derivatives

Huynh Nhu * , Nguyen Thi Thu Tram and Tran Hoang Yen

* Corresponding authorHuynh Nhu

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Received: 10 Oct 2017
Revised: 02 Feb 2018
Accepted: 20 Jul 2018
Published: 31 Jul 2018
DOI: 10.22144/ctu.jen.2018.028
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Huynh, N., Nguyen, T. T. T., & Tran, H. Y. (2018). Synthesis and acute toxicity evaluation of Hantzsch 1,4-dihydropyridine derivatives. CTU Journal of Innovation and Sustainable Development , 54(09), 77-80. https://doi.org/10.22144/ctu.jen.2018.028
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No. 09 (2018)

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Abstract

Derivatives of 1,4-dihydropyridines are well known as calcium channel modulators for the treatment of cardiovascular disorders. Herein, three 1,4-dihydropyridines were synthesized through the condensation of an aldehyde, a β-ketoester, and ammonium acetate in ethanol with yields ranging from 23 to 59%. Their structures were confirmed by comparison HRMS, NMR spectral data with the literature. The acute oral toxicity study for the synthesized compounds revealed that all compounds were safe up to 2000 mg/kg and no deaths of animals were recorded. 
Keywords: 1, 4-dihydropyridines, acute toxicity, Hantzsch ester, β-ketoester

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