Rahen Mahmuda * , Tran Quang De , Negar Sultana Shoshi , Khadija Akhter Poly , Pranoy Saha , Sukumar Bepary , Shahenul Islam and Shamima Akhter

* Correspondence: Rahen Mahmuda

Main Article Content


Resorcinol with its two hydroxyl groups was derivatized in laboratory to observe the anti-inflammatory potential in vitro. Subsequently in silico docking analysis was done for observing the binding modes in cyclooxygenase enzyme to have idea about the subsequent possible developments. At the doses of 200 mg/ml and 400 mg/ml. the compounds showed the anti-inflammatory property, where 02 offered dose dependent 51% and 70% of inhibition of heat induced hemolysis respectively. The scaffold thus poses as an interesting pharmacophore suitable for lead generation for the inflammatory disorders.
Keywords: Anti-inflammatory, docking, nitrobenzoic acid, resorcinol

Article Details


da Silva Guerra, A. S. H., do Nascimento Malta, D. J., Laranjeira, L. P. M., et al., 2011. Anti-infammatory and antinociceptive activities of indole-imidazolidine derivatives. Int. Immunopharmacol., 11(11): 1816–1822. DOI 10.1016/j.intimp.2011.07.010.

dos Santos, J. L., Moreira, V., Campos, M. L., et al., 2012. Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect. Int. J. Mol. Sci. 13(11): 15305-15320. DOI 10.3390/ijms131115305.

Elhenawy, A. A., El-Gazzar, M. A., and Mohmmed, H. M., 2014. Synthesis, anti-Infammatory, analgesic, molecular modeling and ADMET studies of novel diclofenac derivatives containing alanyl moiety. Chemistry and Materials Research. 6(2): 69–77. DOI doi.org/10.7176/CMR

Goldstein, J. L. and Cryer, B., 2015. Gastrointestinal injury associated with NSAID use: a case study and review of risk factors and preventative strategies. Drug Healthc Patient Saf. 7: 31–41. DOI 10.2147/DHPS.S71976.

Jane, A. M. and Nicholas, S. K., 2019. Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system. Br. J. Pharmacol. 176: 1038–1050. DOI 10.1111/bph.14167.

Okoli, C. O., Akah, P. A., Onuoha, N. J., Okoye, T. C., Nwoye, A. C. and Nworu, C. S., 2008. Acanthus montanus: An experimental evaluation of the antimicrobial, anti-inflammatory and immunological properties of a traditional remedy for furuncles. BMC Complementary and Alternative Medicine.8: 27. DOI 10.1186/1472-6882-8-27.

Orlando, B. J., Lucido, M. J. and Malkowski M. G., 2015. The structure of ibuprofen bound to cyclooxygenase-2. J. Struct. Biol. 189: 62. DOI 10.2210/pdb4PH9/pdb.

Suryawanshi, S. B., Osman, H. A., Shaikh, Y. I. and Nazeruddin, G. M., 2014. Synthesis of Various esters of diclofenac (NSAIDs) as pro-drugs and their biological evaluation. Chemical Science Transactions. 3: 562–565. DOI 10.7598/cst2014.745.

Trott, O. and Olson, A. J., 2010. AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading, J. Comput. Chem. 31(2): 455-461. DOI 10.1002/jcc.21334.