Quoc Luan Ngo * , Nguyen Phu Thach , Nguyen Van Minh Em , Nguyen Thi Ngoc Trinh , Phan Nhu Thao , Ngo Khac Khong Minh , Ngo Trong Nghia , Phan Nhat Minh and Nguyen Tan Phat

* Correspondence: Quoc Luan Ngo (email: ngoquocluan@ctu.edu.vn)

Main Article Content

Abstract

In this report, the extracts from the fruit and leaves of Couroupita guianensis were isolated using chromatographic methods and investigated for chemical composition. Four triterpenoid compounds were isolated and identified as betulinic acid, oleanolic acid, β-amyrin and friedelin. Their chemical structures were interpreted based on modern spectra such as MS, NMR and compared with previously published spectral data.

Keywords: Couroupita guianensis, betulinic acid, oleanolic acid, -amyrin, friedelin

Article Details

References

Begum, R., Rahman, M. S., Chowdhury, A. M. S., Hasan, C. M. & Rashid, M. A. (2009). Secondary metabolites (Triterpenes) from Couroupita guianensis. Oriental Pharmacy and Experimental Medicine, 9(2), 200–205. DOI:10.3742/OPEM.2009.9.2.200

Cardoso, B. K., Oliveira, H. L .M, Melo, U. Z., Fernandez, C. M. M., Campo, C. F. A. A, Gonçalves, J. E., Jr, A. L., Romagnolo, M. B., Linde, G. A. & Gazim, Z. C. (2018). Antioxidant activity of α and β-amyrin isolated from Myrcianthes pungens leaves. Natural Product Research, 34(2), 1–5, DOI:10.1080/14786419.2018.1525715

Chirchir, K. D., Cheologoi, K. P., Omolo, O. J. & Langat, K. M. (2018). Chemical constituents of Solanum mauense (Solanaceae) and Dovyalis abyssinica (Salicaceae). International Journal of Biological and Chemical Sciences, 12(2), 999–1007. DOI:10.4314/ijbcs.v12i2.29

Chudzik, M., Korzonek-Szlacheta, I. & Krol, W. 2015. Triterpenes as potentially cytotoxic compounds. Molecules, 20(1), 1610–1625. DOI:10.3390/molecules20011610

Ho, P. H. (2003). “Vietnamese plants”- An illustrated flora of Vietnam, Vol. 2. Tre Publisher, HCM City, p.21 (in Vietnamese).

Nelson, E. K. & Wheeler, D. H., 1937. Some constituents of the Cannonball fruit (Couroupita guianensis Aubl.). Journal of the American Chemical Society, 59(12), 2499–2500. DOI:10.1021/ja01291a005

Paszel-Jaworska, A., Romaniuk, A. & Rybczynska, M. (2014). Molecular mechanisms of biological activity of oleanolic acid - A Source of inspiration for a new drugs design. Mini-Reviews in Organic Chemistry, 11(3), 330–342. DOI:10.2174/1570193X1103140915111839

Ragasa, C. Y., Jr V. E., Reyes, M. M. L., Mandia, E. H., Brkljaca, R. & Urban, S. (2015). Triterpenes from Calophyllum inophyllum Linn. International Journal of Pharmacognosy and Phytochemical Research, 7(4), 718–722. DOI:10.1016/S0040-4020(01)82592-8

Thirupathi, A., Silveira, P. C., Nesi, R. T & Pinho, R. A. (2017). β-Amyrin, a pentacyclic triterpene, exhibits anti-fibrotic, anti-inflammatory, and anti-apoptotic effects on dimethyl nitrosamine–induced hepatic fibrosis in male rats. Human and Experimental Toxicology, 36(2), 113–122. DOI:10.1177/0960327116638727

Güvenalp Z., Özbek H., Ayşe Kuruüzüm-Uz, Kazaz C. & Ömür Demirezer L. (2009). Secondary metabolites from Nepeta heliotropifolia. Turk Journal of Chemistry, 33, 667–675. DOI:10.3906/kim-0812-60

Most read articles by the same author(s)