Le Thi Bach , Trinh Minh Thanh Nam , Nguyen Trong Tuan , Hoang Trung Vinh , Le Tien Dung , Le Thi Thanh Xuan and Bui Thi Buu Hue *

* Correspondence: Bui Thi Buu Hue (email: btbhue@ctu.edu.vn)

Main Article Content


Eclipta prostrata (L.) L. belonging to the Astearaceae family has been long used worldwide by various communities as a traditional medicine. We studied the antibacterial activity of different extracts from Eclipta prostrata (L.) L. against Aeromonas hydrophila, Aeromonas dhakensis, and Vibrio parahaemolyticus . The processing of this extract using repeated column and thin layer chromatographic techniques resulted in the isolation of three compounds including luteolin (1), kaempferol (2), and kaempferol-3-O-α-L-rhamnopyranoside (3), which were identified by NMR. Among them, kaempfreol-3-O-α-L-rhamnopyranoside was isolated for the first time and shows good antibacterial activity against Aeromonas hydrophila which is major pathogen for the aquaculture industry. The results demonstrate the beneficial effects of E. prostrata as an antimicrobial and bioactive compound for medicinal usages.


Keywords: Eclipta prostrata (L.) L., flavonoid, antibacterial activity

Article Details


Alwahsh, M. A. A., Khairuddean, M., & Chong, W. K. (2015). Chemical constituents and antioxidant activity of Teucrium barbeyanum Aschers, Records of Natural Products, 9 (1), 159-163.

Borkataky, M. U. N. M. I., Kakoty, B. B., & Saikia, L. R. (2013). Proximate analysis and antimicrobial activity of Eclipta alba (L.) Hassk.- a traditionally used herb. International Journal of Pharmacy and Pharmaceutical Sciences5(1), 149-154.

Chung, I. M., Rajakumar, G., Lee, J. H., Kim,        S. H., & Thiruvengadam, M. (2017). Ethnopharmacological uses, phytochemistry, biological activities, and biotechnological applications of Eclipta prostrataApplied Microbiology and Biotechnology101(13), 5247-5257.

Gani A.M.S., Devi D.N. (2015). Antioxidant activity of methanolic extract of Eclipta prostrata (L.) L. International Journal of Phytopharmacy, 5(2), 21-24.

Ghaly, N. S., Mina, S. A., Abdel-Aziz, N. F., & Sammour, E. A. (2014). Insecticidal activity of the main flavonoids from the leaves of Kalanchoe beharensis and Kalanchoe longifloraJournal of Natural Products7, 196-202.

Hossein, J., Jelas, H.M.D., Mohd, H.S.I., Roshanak, R.M., Leili, A.H.D., Yadollah, A.E., Majid, R.C., Nazanin, V.F. (2013). Well diffusion method for evaluation of antibacterial activity of copper phenyl fatty Hydroxamate synthesized from canola and palm kernel oils. Digest Journal of Nanomaterials and Biostructures, 8 (3), 1263-1270.

Jaisin, Y., Ratanachamnong, P., Prachayasittikul, S., Watanapokasin, R., & Kuanpradit, C. (2016). Protective effects of ethyl acetate extract of Eclipta prostrata against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. Science Asia42, 259-265.

Nenadis, N., Wang, L. F., Tsimidou, M., & Zhang, H. Y. (2004). Estimation of scavenging activity of phenolic compounds using the ABTS•+ assay. Journal of Agricultural and Food Chemistry52(15), 4669-4674.

Sharma, S., & Richa, H. (2017). Phytochemical and anatomical screening of Eclipta prostrata L. An important medicinal herb from Chandigarh. Journal of Medicinal Plants5(2), 255-258.

Yu, S. J., Yu, J. H., He, F., Bao, J., Zhang, J. S., Wang, Y. Y., & Zhang, H. (2020). New antibacterial thiophenes from Eclipta prostrata. Fitoterapia142, 104471.

Most read articles by the same author(s)

1 2 > >>